Cranial Nerves Tractography (CN Tracto)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Cranial Nerve Palsy

Treatments: Procedure: preoperative cerebral MRI and operative findings

Study type: Interventional

Funder types: Other

Identifiers

NCT02978911

2015-A01113-46 (Other Identifier)

69HCL16_0759

Details and patient eligibility

About

Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and visualizing functional tracts. Cranial nerves tractography could allow predicting their displacement by skull base tumors that may help the surgeon to spare them along the surgery.

Methods: Preoperative cerebral MRI was performed on patients who presented with skull base tumors. A 3 tesla MRI machine was used to acquire DTI sequence with specific parameters: 32 directions, slice thickness 2 mm, echo time 86 ms, repetition time 12000 ms, matrix 128x128, b-value 1000 s.mm-1. An anatomic sequence hyperT2 was overlaid as reference. Distortion was corrected by topup and eddy functions from FSL. Cranial nerves fibers were probabilistically tracked with Mrtrix3. Cranial nerves were selected according to their location around the tumor. The "radiological" expected position of the cranial nerve was compared to its "operative" real position.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who present a skull base tumor that requires surgical removal
• Patients adult, informed and agreed

Exclusion criteria

• Pregnant women
• Patients under 18 years old, unable to legally consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

Skull base tumors

Experimental group

Description:

Patients who presented a skull base tumor that requires a surgical removal

Treatment:

Procedure: preoperative cerebral MRI and operative findings