Craving Network Neurofeedback

Yale University

Status: Enrolling

Conditions: Overweight or Obesity

Treatments: Device: Control feedback; Device: Experimental feedback

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06426693

1R01DK136623-01A1 (U.S. NIH Grant/Contract)

2000037084

Details and patient eligibility

About

This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.

Full description

Aim 1 of this study is to test whether neurofeedback from the craving network is associated with reduced craving network strength.

Aim 2 of this study is to test whether neurofeedback from the craving network is associated with reduced food craving and changes in eating behavior.

Aim 3 of this study is to test whether neurofeedback from the craving network is associated with changes in resting state functional connectivity.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18 to 60 years
• Body mass index >25 kg/m2
• >2.37 Food Craving Inventory score

Exclusion criteria

• Current or past 6 months use of anti-obesity medications
• Weight-reduced state defined as >10% weight reduction in the past 6 months.
• Nicotine use
• Current diagnosis of neurological or psychiatric disorder
• Obesity-related diseases such as type-2 diabetes
• Contraindications to MRI
• Baseline scanning with motion >0.15mm frame to frame displacement.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Neurofeedback

Experimental group

Description:

Three imaging (fMRI) sessions of experimental feedback.

Treatment:

Device: Experimental feedback

Control neurofeedback

Sham Comparator group

Description:

Three imaging (fMRI) sessions of sham feedback.

Treatment:

Device: Control feedback