Creatine and Ubiquinol for Sperm Quality (CRESPAQ10)

University of Novi Sad, Faculty of Sport and Physical Education

Status: Completed

Conditions: Oligospermia; Sperm Count, Low

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Supplement 2; Dietary Supplement: Supplement 1

Study type: Interventional

Funder types: Other

Identifiers

NCT06202469

CR-24-AK15

Details and patient eligibility

About

This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

Enrollment: 18 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 - 35 years
• Sperm quality test available (at least half will have low sperm quality)
• Informed consent
• Healthy BMI (18.5 - 24.9 kg/m2)

Exclusion criteria

• Major chronic disease and acute injuries
• History of dietary supplement use during the past 28 days
• No consent to randomization
• Participation in other studies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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18 participants in 3 patient groups, including a placebo group

Supplement 1

Experimental group

Description:

Creatine monohydrate

Treatment:

Dietary Supplement: Supplement 1

Supplement 2

Experimental group

Description:

Creatine monohydrate plus ubiquinol

Treatment:

Dietary Supplement: Supplement 2

Placebo

Placebo Comparator group

Description:

Inulin

Treatment:

Dietary Supplement: Placebo