Creatine-Guanidinoacetic Acid Supplementation for Sarcopenia (CREGAAS)

University of Novi Sad, Faculty of Sport and Physical Education

Status: Completed

Conditions: Sarcopenia

Treatments: Other: Inulin; Dietary Supplement: Creatine-guanidinoacetic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT04652921

DS-04/2020

Details and patient eligibility

About

Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.

Enrollment: 30 patients

Sex: All

Ages: 65 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age > 70 years
• Free of acute disorders

Exclusion criteria

• History of dietary supplement use during the past 4 weeks

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Creatine-guanidinoacetic acid

Experimental group

Description:

2 grams of creatine and 2 grams of GAA Administered one dose two times per day on an empty stomach in the morning and at the evening

Treatment:

Dietary Supplement: Creatine-guanidinoacetic acid

Inulin

Placebo Comparator group

Description:

4 grams of inulin Administered one dose two times per day on an empty stomach in the morning and at the evening

Treatment:

Other: Inulin