Creatine Monohydrate Versus Creatine Hydrochloride on Strength and Body Composition in Elite Team-Sport Athletes (CrM_CrHCl)

Dynamical Business and Science Society - DBSS International SAS

Status: Completed

Conditions: Healthy Lifestyle

Treatments: Dietary Supplement: Creatine Hydrochloride; Dietary Supplement: Creatine Monohydrate; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT05697900

Acta161_N°994

Details and patient eligibility

About

A triple-arm double-blinded placebo-controlled repeated-measures randomized clinical trial in Colombian elite team-sport athletes. The aim is to evaluate the effects on strength-related parameters and body composition after eight weeks of supplementation with creatine monohydrate (CrM) and creatine hydrochloride (Cr-HCl). The study will be reported following the Consolidated Standards of Reporting Trials (CONSORT) extension to Multi-Arm Parallel-Group Randomized Trials. All variables will be measured at baseline and after eight weeks.

Full description

Creatine monohydrate (CrM) is the most studied nutritional supplement and, therefore, one of the most popular ergogenic nutritional aids for athletes. Studies have shown that CrM supplementation increases intramuscular creatine concentrations which enhances exercise performance and improves body composition in different populations (from young athletes to older adults).

It is important to note that the U.S. Food and Drug Administration (FDA) have recognized CrM as a safe ingredient (Generally Recognized as Safe, GRAS - No. GRN 000931). In spite of this, other forms such as creatine chloride (Cr-HCl) have been marketed as a more bioavailable sources of creatine. Since there are not studies that rigorously compare the effects of CrM versus Cr-HCl on physical performance and body composition, the aim of this study is to evaluate the effects of a 8-week supplementation protocol with the two forms of creatine (comparing to placebo) on neuromuscular strength and body composition in Colombian elite team-sport athletes.

Enrollment: 48 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Practicing team sports at the competitive level (handball and softball)
• Having at least one year of competitive sports training experience (including strength training at least three times a week),
• Being attended at INDEPORTES Antioquia.

Exclusion criteria

• Those who do not wish to participate voluntarily (do not sign informed consent),
• Those who were taking nutritional supplements (including creatine) eight weeks prior to the start of the study,
• Those who had a diagnosed pathology or health issues.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 3 patient groups, including a placebo group

Creatine monohydrate

Active Comparator group

Description:

5 g of creatine monohydrate per day for eight weeks

Treatment:

Dietary Supplement: Creatine Monohydrate

Creatine hydrochloride

Experimental group

Description:

5 g of creatine hydrochloride per day for eight weeks

Treatment:

Dietary Supplement: Creatine Hydrochloride

Placebo

Placebo Comparator group

Description:

5 g of maltodextrin per day for eight weeks

Treatment:

Dietary Supplement: Placebo