Creatine Supplementation in Pediatric Rheumatology

University of Sao Paulo

Status: Unknown

Conditions: Juvenile Systemic Lupus Erythematosus; Juvenile Dermatomyositis

Treatments: Dietary Supplement: placebo (dextrose); Dietary Supplement: creatine

Study type: Interventional

Funder types: Other

Identifiers

NCT01217320

Cr in rheumato

Details and patient eligibility

About

Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric rheumatic (i.e., juvenile systemic lupus erythematosus and juvenile dermatomyositis) patients who usually present muscle weakness, muscle wasting and bone mass loss.

Enrollment: 40 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with lupus systemic erythematosus and juvenile dermatomyositis
• physically inactive
• stable pharmacological treatment

Exclusion criteria

• macroalbuminuria
• GFR < 30 mL/min/1.73m2
• use of oral anticontraceptive agents
• pregnancy
• diabetes mellitus
• hypothyroidism

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

creatine supplementation

Experimental group

Description:

will receive 5g/d of creatine monohydrate throughout the trial

Treatment:

Dietary Supplement: creatine

placebo

Placebo Comparator group

Description:

will receive 5g/d of placebo (dextrose) throughout the trial

Treatment:

Dietary Supplement: placebo (dextrose)