Creatine Supplementation in Young Healthy Adults

University of Regina

Status: Enrolling

Conditions: Improve Muscle Performance in Young Adults

Treatments: Dietary Supplement: Creatine; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06604793

834

Details and patient eligibility

About

The purpose is to compare the effects of bolus ingestion (5 grams) vs. intermittent ingestion (2 x 2.5 grams) of creatine supplementation vs. placebo for 21 days on measures of body composition (lean tissue mass-indicator of muscle mass, total body water) and muscle performance (i.e., power, strength, endurance).

Full description

Creatine is a naturally occurring compound produced in the liver and brain. Creatine can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products (i.e. creatine supplementation).

Evidence-based research shows that creatine supplementation improves measures of body composition and muscle performance. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

Enrollment: 42 estimated patients

Sex: All

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• if you are 18-39 years of age
• if you have not been performing resistance training for at least 4 weeks prior to the start of the study.

Exclusion criteria

• if you are pregnant or nursing
• have taken creatine monohydrate within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

42 participants in 3 patient groups, including a placebo group

Creatine Bolus

Experimental group

Description:

(Serving 1: 5 grams of creatine monohydrate + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.

Treatment:

Dietary Supplement: Creatine

Creatine Intermittent

Experimental group

Description:

(Serving 1: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the morning; Serving 2: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the evening) for 21 days.

Treatment:

Dietary Supplement: Creatine

Placebo

Placebo Comparator group

Description:

(Servings 1: 8 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.

Treatment:

Dietary Supplement: Placebo