Creation of a Biological Collection for Medical Research Purposes for Patients at the Reference Center for Rare Diseases of the Blood Vessels of the Brain and Eye at Lariboisière Hospital (B-MRVC)

Assistance Publique - Hôpitaux de Paris

Status: Active, not recruiting

Conditions: Cerebrovascular Disease

Treatments: Other: additional samples for research purposes

Study type: Observational

Funder types: Other

Identifiers

NCT07264972

APHP200773

Details and patient eligibility

About

The aim of establishing a biological collection associated with the existing rare cerebral vascular disease cohort is to identify new prognostic or disease progression biomarkers that could improve patient care or identify new therapeutic targets.

Enrollment: 500 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed diagnosis of a rare cerebral vascular disease of the brain, including:

Familial intracranial aneurysms, cerebral amyloid angiopathy, CADASIL, familial cerebral cavernoma, familial cervical or intracranial artery dissection, vascular leukoencephalopathy (hereditary), familial hemiplegic migraine, cerebral arteriovenous malformation, moya-moya, cerebral venous thrombosis, hereditary retinal tortuosity, cerebro-retinal vasculopathies, other known rare diseases, or other rare diseases that are undetermined or not yet described.

• Participation in the MVCR cohort
• Adults >18 years old
• Affiliation with French social security or beneficiary - Signature of informed consent

Exclusion criteria

• Incompatibility with long-term follow-up at CERVCO
• Patient under guardianship/conservatorship
• Pregnant or breastfeeding women
• Patient under AME

Trial design

500 participants in 1 patient group

Patients with rare cerebrovascular disease

Treatment:

Other: additional samples for research purposes