Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases (ALS-PHENO)

Istituto Auxologico Italiano

Status: Enrolling

Conditions: Motor Neuron Disease; Amyotrophic Lateral Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT06318585

23C306

Details and patient eligibility

About

Study Description: Characterization of Motor Neuron Disease Phenotypes

The goal of this observational study is to understand the clinical presentation of motor neuron disease (MND) in patients attending the Neurology Department of the Istituto Auxologico Italiano. The main questions it aims to answer are:

• What are the specific clinical phenotypes associated with MND?
• How can these phenotypes contribute to a better understanding of the disease's underlying mechanisms and improve prognostic accuracy?

Participants will undergo:

• Clinical evaluation using validated scales
• Neurophysiological and neuroradiological instrumental assessment
• Neuropsychological evaluation
• Collection of biological materials for genetic screening and biomarker assessment, if necessary.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of ALS or other motor neuron disease

Exclusion criteria

• refusal to participate to the study