Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients

Clinical Institute of the Brain, Russia

Status: Completed

Conditions: Critical Illness; Muscle Weakness

Study type: Observational

Funder types: Other

Identifiers

NCT00893633

CINMAs-2004

Details and patient eligibility

About

The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.

Full description

Since 1984, the problem of critical illness neuromuscular abnormalities (CINMAs) has attracted considerable interest. According to these studies, CINMAs include the muscular weakness that accompanies critical illness resulting from polyneuropathy and/or myopathy and can be seen in 25-85% of cases of critically ill patients. Clinically, CINMAs present as symmetric flaccid tetraparesis and difficulty weaning off mechanical lung ventilation. However, these data are derived from treating non-specialized intensive care unit (ICU) patients. In this research, we wished to investigate CINMAs in neurocritical care patients. From day one of the patients' participation in the research and until a discharge from the ICU (or death), daily neurological surveys and weekly nerve conduction studies were performed. Based on the results of each nerve conduction study, an index of neuromuscular damage was noted to evaluate the severity of the CINMAs. Needle electromyography and muscle biopsy were not used

Enrollment: 135 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 16 years and older
• Acute primary cerebral pathology
• Mechanical ventilation
• Signs of systemic inflammatory response
• Exclusion of the possibility of an initial pathology of the spinal cord, peripheral nervous system and muscles in past medical history

Exclusion criteria

• Brain stem or bilateral hemispheric lesions with tetraparesis at the onset of illness
• Inability to perform high-grade nerve conduction studies