Cross-cultural Adaptation and Validation of the P-CIN for Chinese Pediatric Oncology Patients

The Hong Kong Polytechnic University

Status: Completed

Conditions: Pediatric Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT07053579

Validation study_P-CIN

Details and patient eligibility

About

The goal of this study was to conduct a cross-cultural adaptation of the P-CIN into the Chinese context, assess its psychometric properties, and determine the cut-off value of CIPN among Chinese pediatric oncology patients.

Participants provided demographic and clinical characteristics, and complete the translated P-CIN, Wong-baker FACES Pain Rating scale for pain, and Chinese version of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module for quality of life.

Full description

A methodological, descriptive study was conducted.

Enrollment: 313 patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) 6 to 18 years of age
• (2) were diagnosed with cancer
• (3) had received or were currently receiving neurotoxic chemotherapy drugs (e.g., Vincristine, Cisplatin, Carboplatin, Oxaliplatin, Paclitaxel, Docetaxel, Ixabepilone, Bortezomib, Thalidomide)
• (4) were able to communicate, read, and write in Chinese without significant hearing and vision problems to ensure they understood the P-CIN.

Exclusion criteria

• (1) had a diagnosis of cancer in the central nervous system (CNS) cancer, cancer relapse or secondary cancer
• (2) in the terminal stage
• (3) planned to receive multiple cancer treatment (e.g., radiotherapy and immunotherapy)
• (4) suffered from other neuromuscular diseases (e.g., traumatic brain injury and cerebral palsy)
• (5) had a developmental deficit (e.g., Down's syndrome and other chromosomal disorders)
• (6) have suffered from psychiatric diseases or used antipsychotic drugs
• (7) had peripheral neuropathy symptoms caused by diabetes, genetic diseases, spinal cord injury, or alcoholism, or
• (8) had other neuromuscular disorders (e.g., traumatic brain injury, cerebral palsy).

Trial design

313 participants in 1 patient group

Questionnaire

Description:

Participants completed the translated P-CIN, Wong-baker FACES Pain Rating scale for pain, and Chinese version of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module for quality of life.