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Cross-linking as Treatment in Infectious Keratitis

S

Sohag University

Status

Completed

Conditions

Infectious Keratitis

Treatments

Procedure: PACK-CXL

Study type

Interventional

Funder types

Other

Identifiers

NCT04383431
4-9/12/2018

Details and patient eligibility

About

To compare between SCXL and ACXL for treatment of infectious keratitis

Full description

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

Enrollment

37 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Fungal infectious keratitis
  • bacterial infectious keratitis
  • Must be not responding to medication

Exclusion criteria

  • Viral keratitis
  • Pregnancy and lactation

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

37 participants in 2 patient groups

Standard CXL
Experimental group
Description:
Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode.
Treatment:
Procedure: PACK-CXL
Accelerated CXL
Experimental group
Description:
Accelerated epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation continuous mode.
Treatment:
Procedure: PACK-CXL

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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