Cross-linking as Treatment in Infectious Keratitis

Sohag University

Status: Completed

Conditions: Infectious Keratitis

Treatments: Procedure: PACK-CXL

Study type: Interventional

Funder types: Other

Identifiers

NCT04383431

4-9/12/2018

Details and patient eligibility

About

To compare between SCXL and ACXL for treatment of infectious keratitis

Full description

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

Enrollment: 37 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fungal infectious keratitis
• bacterial infectious keratitis
• Must be not responding to medication

Exclusion criteria

• Viral keratitis
• Pregnancy and lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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37 participants in 2 patient groups

Standard CXL

Experimental group

Description:

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode.

Treatment:

Procedure: PACK-CXL

Accelerated CXL

Experimental group

Description:

Accelerated epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation continuous mode.

Treatment:

Procedure: PACK-CXL