CRRT for Glutamate Elimination After Cardiac Arrest (GCRRT)

C. Storm

Status: Completed

Conditions: Reperfusion Syndrome

Treatments: Procedure: Continuous renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02963298

Glu2016

Details and patient eligibility

About

Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• post cardiac arrest

Exclusion criteria

• hemodynamic instable
• in-hospital cardiac arrest

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 2 patient groups

CRRT after cardiac arrest

Active Comparator group

Description:

Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels.

Treatment:

Procedure: Continuous renal replacement therapy

control

No Intervention group

Description:

Repetitive testing of blood Glutamate levels without CRRT