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Cryogenic Preservation of Spermatozoa

U

University Hospital, Clermont-Ferrand

Status

Completed

Conditions

Spermatic Parameters
Fertility

Treatments

Other: cryopreservation

Study type

Observational

Funder types

Other

Identifiers

NCT03734120
CHU-413

Details and patient eligibility

About

The reference technique for the conservation of gametes is storage in liquid nitrogen but new vats of nitrogen vapor (storage over liquid nitrogen) or in dry phase (storage in an insulated compartment of liquid nitrogen in a tank Liquid nitrogen) also allow the storage of flakes. The purpose of this work is to evaluate the dry-phase cryopreservation technique of liquid nitrogen compared with liquid-phase storage, depending on the duration of cryopreservation.

Full description

Objective: To evaluate the effects of cryopreserved sperm in dry and liquid phase nitrogen at 3 and 6 month on sperm numeration, motility, vitality, morphology, acrosomal integrity and DNA fragmentation.

Design: Experimental study, investigator was blinded to the type of Cryopreservation.

Patient(s): Semen samples were collected from patients who came in laboratory for semen analysis

Intervention: Samples were frozen with a programmable freezing unit. Each semen sample was divided into two aliquots. One aliquot was plunged into liquid nitrogen and the other was stored in dry-phase nitrogen for 3 or 6 month. Thawing was performed at room temperature.

Enrollment

52 patients

Sex

Male

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Men undergoing routine semen analysis for infertility for reproductive medicine of university hospital in Clermont-Ferrand

Exclusion criteria

  • women

Trial design

52 participants in 1 patient group

men
Description:
men undergoing routine semen analysis for infertility
Treatment:
Other: cryopreservation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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