Cryopreserved Human Meniscus Transplantation

Cincinnati Sportsmedicine Research and Education Foundation

Status: Completed

Conditions: Osteoarthritis

Treatments: Procedure: Cryopreserved meniscus transplants

Study type: Observational

Funder types: Other

Identifiers

NCT02319811

MenisCryo-001

Details and patient eligibility

About

The purpose of this study is to determine the long-term survivorship and clinical outcomes of all cryopreserved meniscus transplants performed by Dr. Frank Noyes.

Full description

All patients receiving cryopreserved meniscus transplants will be followed at 1, 2, 5, 10, and 15 years postoperatively. Study examination will include comprehensive knee examination by Dr. Noyes, x-rays, and potentially MRI. Patients will complete the following forms of the Cincinnati Knee Rating System: Symptom Rating Form, Sports Activity and Function Form, and Occupational Rating Form. All patient identification will be kept confidential. Patient data will be entered into the Knee Registry database according to their unique study number by the clinical research assistant.

Enrollment: 76 patients

Sex: All

Ages: 14 to 49 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient post-meniscectomy
• Patient symptomatic with activities
• Patient has early articular cartilage degeneration in affected tibiofemoral compartment
• Patient understands goals of operation, willing to undergo lengthy rehabilitation

Exclusion criteria

• Patient has no symptoms with activities
• Patient has advanced degeneration in affected tibiofemoral compartment or other compartments
• Patient is obese (BMI > 30)
• Patient has uncorrected lower limb axial malalignment or knee ligament deficiency
• Patient has active infection
• Patient has pre-existing knee arthrofibrosis or lower limb muscular atrophy
• Patient has symptomatic patellofemoral articular cartilage deterioration
• Patient is unwilling to undergo lengthy rehabilitation after surgery

Trial design

76 participants in 1 patient group

Cryopreserved meniscus transplant

Description:

Intervention: Lateral or medial cryopreserved meniscus transplant implanted into appropriately indicated patients.

Treatment:

Procedure: Cryopreserved meniscus transplants