Cryospray to Reduce Pain During Venous Cannulation

University of Southern Denmark (SDU)

Status: Completed

Conditions: Elective Surgical Procedures; Anesthetics, Intravenous; Catheterization

Treatments: Procedure: Cryospray; Procedure: Saline spray

Study type: Interventional

Funder types: Other

Identifiers

NCT04865783

SHS-BI-4a-2021

Details and patient eligibility

About

This trial aims to evaluate if cryospray can reduce pain during intravenous cannulation in elective surgery compared to a placebo spray.

Full description

Venous cannulation is a common practice in the health care system. Before any procedure, intravenous access is always placed before induction of any anaesthesia. For many patients placement of a venous catheter is associated with pain and discomfort. Any quick and easy reduction in pain during the procedure is important for patients. Cryospray has been described as an easy-to-use supplement of analgesia to alleviate pain during intravenous access. Cryospray has been shown to reduce pain in venous cannulation in the emergency setting but not in the elective setting. A search in the literature reveals 2 recent metanalyses reporting 8 included trials and 11 included trials, respectively. Both metanalyses call for further research in relation to patients' satisfaction. By randomizing patients to either cryospray or placebo before venous cannulation, we hypothesize that cryospray reduces pain during venous cannulation compared to placebo.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older and able to give consent

Exclusion criteria

• Unable to give consent
• Infection
• coloring or bruises at the puncture site (use of corticosteroid etc).
• No vein signs visible after application of vein stasis.
• Allergy to coolant spray.
• Contraindication for vein stasis or vein cannulation (ex Raynauds disease etc).
• Has participated earlier in the trial.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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130 participants in 2 patient groups, including a placebo group

Cryospray

Active Comparator group

Description:

Cryospray will be sprayed from a distance of 20-30 cm to the back of one hand.

Treatment:

Procedure: Cryospray

Placebo

Placebo Comparator group

Description:

A saline solution will be sprayed from a distance of 20-30 cm to the back of the hand.

Treatment:

Procedure: Saline spray