Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors

Sohag University

Status

Completed

Conditions

Cryotherapy Effect

Bronchial Neoplasms

Treatments

Procedure: Endobronchial cryobiopsy and cryotherapy using flexible bronchoscopy

Study type

Interventional

Funder types

Other

Identifiers

NCT06531265

Soh-Med-24-06--01PD

Details and patient eligibility

About

This study was to assess the diagnostic yield and the safety of bronchoscopic cryotechniques in the management of endobronchial tumors.

Full description

Novel flexible cryoprobes were introduced for tissue sampling during bronchoscopy. Employing this approach, the sample is collected when frozen, with the tissue attached to the frozen end of the probe. This approach enables the retrieval of larger tissue samples from endobronchial lesionsEndobronchial cryotherapy is employed to treat individuals with obstructive central bronchial lung cancers. It has been demonstrated to effectively recanalize obstructed respiratory passages, alleviate symptoms, and improve the quality of life for patients in advanced stagesThis study aimed to assess the effectiveness and safety of using bronchoscopic cryotechniques for diagnosing and treating endobronchial malignancies.

Enrollment

35 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with radiologically suspected endobronchial masses

Exclusion criteria

Patients with contraindications to bronchoscopy.
uncorrected coagulopathy (if the international normalized ratio (INR) is more than 1.5).
severe refractory hypoxemia (even after administering the highest possible dose of oxygen, the partial pressure of oxygen ("PaO2") stays below 70 mm Hg.
hypoventilation with hypercapnia (type 2 respiratory failure).
severe pulmonary hypertension > 55 mmHg by echocardiography.
hemodynamic instability.