Cryotherapy as a Coadjuvant in Crotaline Snakebite Management With Antivenom.

Hospital Juarez de Mexico

Status: Completed

Conditions: Snake Bites

Treatments: Procedure: Local cryotherapy.; Biological: F(ab)2 antivenom therapy (antivipmyn®).

Study type: Interventional

Funder types: Other

Identifiers

NCT04470791

HJM 0142/16-R (Other Identifier)

Details and patient eligibility

About

The study aimed to determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with F(ab')2 therapy venom at the Hospital Juárez de Mexico.

Full description

Introduction: Local cryotherapy induces vasoconstriction, which leads to a reduction in the inflammatory process. However, the efficacy of local cryotherapy as a coadjuvant in snakebite treatment with F(ab')2 antivenom is unknown.

Objective: Determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with F(ab')2 therapy venom.

Material and methods: Subjects with snakebite envenomation accident grade II, according to the Christopher-Rodning classification, were enrolled from the Clinical Toxicology Service of the Hospital Juárez de México. One group of patients received F(ab')2 antivenom therapy (antivipmyn®) plus local cryotherapy, and another group received only F(ab')2 antivenom therapy.

Enrollment: 38 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of both genders and any age with a snake bite of poison grade II who were admitted to the Clinical Toxicology Service of the Hospital Juárez de México.

Exclusion criteria

• Patients of both genders and any age with a snake bite of poison grade I, III or IV who were admitted to the Clinical Toxicology Service of the Hospital Juárez de México.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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38 participants in 2 patient groups

F(ab')2 antivenom plus local cryotherapy.

Experimental group

Description:

Group A: patients with a Crotalus snakebite, and grade II envenomation received F(ab')2 antivenom therapy and application of local cryotherapy.

Treatment:

Procedure: Local cryotherapy.

Biological: F(ab)2 antivenom therapy (antivipmyn®).

F(ab')2 antivenom.

Active Comparator group

Description:

Group B: patients who received only F(ab')2 antivenom therapy.

Treatment:

Biological: F(ab)2 antivenom therapy (antivipmyn®).