Cryotherapy Versus Dexamethasone on Postoperative Pain in Permanent Mandibular Molars

Çukurova University

Status: Completed

Conditions: Pulpitis - Irreversible

Treatments: Drug: Dexamethasone; Other: Cryotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06832254

13.02.2025/151

Details and patient eligibility

About

The goal of this clinical trial was to evaluate cryotherapy versus dexamethasone on the intensity of postoperative pain in root canal treatment procedures in mandibular first molar teeth with symptomatic irreversible pulpitis. The main question it aims to answer is:

• Does controlled irrigation with cold saline in root canal treatment reduce the severity of postoperative pain?
• Does controlled irrigation with dexamethasone in root canal treatment reduce the severity of postoperative pain? In the cryotherapy group, unlike the control and dexamethasone group, the root canals were irrigated with 2 °C salin solution in final irrigation.

In the dexamethasone group, unlike the control and cryotherapy group, the root canals were irrigated with 1 mL dexamethasone solution in final irrigation.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Vital mandibular first and second molars with 3 root canals that responded positively to the cold test and electric pulp test
• Patients who had not taken analgesics or antibiotics in the last 24 hours before the procedure were included in the study.

Exclusion criteria

• Devital mandibular first and second molars that responded negatively to cold tests and electric pulp tests
• Mandibular first and second molars with poor periodontal status (pocket depth > 4 mm),
• Mandibular first and second molars with 4 or more root canals detected radiographically or after opening the endodontic access cavity were excluded from the study.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 3 patient groups

Control Group

No Intervention group

Description:

Irrigation was performed with a 30 G navitip needle and 2.5% sodium hypochlorite (NaOCl). A total of 11 mL of NaOCl was used in each root canal, 2 mL after coronal preparation, 2 mL after middle third preparation, 2 mL after apical third preparation and 5 mL in the final irrigation. After irrigation with NaOCl, each root canal was irrigated with 2 mL saline, 2 mL 17% EDTA and finally all canals were irrigated with a total of 20 mL of normal saline for 5 minutes.

Cryotherapy Group

Experimental group

Description:

Irrigation was performed with a 30 G navitip needle and 2.5% sodium hypochlorite (NaOCl). A total of 11 mL of NaOCl was used in each root canal, 2 mL after coronal preparation, 2 mL after middle third preparation, 2 mL after apical third preparation and 5 mL in the final irrigation. After irrigation with NaOCl, each root canal was irrigated with 2 mL saline, 2 mL 17% EDTA and finally all canals were irrigated with a total of 20 mL of cold (2 °C) saline for 5 minutes.

Treatment:

Other: Cryotherapy

Dexamethasone Group

Experimental group

Description:

Irrigation was performed with a 30 G navitip needle and 2.5% sodium hypochlorite (NaOCl). A total of 11 mL of NaOCl was used in each root canal, 2 mL after coronal preparation, 2 mL after middle third preparation, 2 mL after apical third preparation and 5 mL in the final irrigation. After irrigation with NaOCl, each root canal was irrigated with 2 mL saline, 2 mL 17% EDTA, 2 mL saline and 1 mL dexamethasone.

Treatment:

Drug: Dexamethasone