Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia

Seoul National University

Status: Completed

Conditions: Hypotension; Cesarean Delivery; Pregnancy

Treatments: Other: Crystalloid; Other: Colloid

Study type: Interventional

Funder types: Other

Identifiers

NCT03729076

H-1807-152-961

Details and patient eligibility

About

The study aims to compare crystalloid co-loading and colloid co-loading in parturients receiving prophylactic phenylephrine infusion during cesarean delivery in terms of the incidence of hypotension.

Enrollment: 100 patients

Sex: Female

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy, full-term parturients who scheduled to undergo elective cesarean delivery under spinal anesthesia.

Exclusion criteria

• multiple pregnancy

  • gestational age < 36 weeks

    • preexisting or pregnancy-induced hypertension

      • Morbid cardiovascular impairments

        • Cerebrovascular disease

          ⑥ Known fetal anomaly

          ⑦ Contraindications to spinal anesthesia

          ⑧ Any sign of onset of labor

          ⑨ Body weight < 45 kg or body weight > 90 kg

          ⑩ Height < 145cm or height > 180cm

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Crystalloid

Experimental group

Description:

Patients will receive rapid co-load of plasma solution A (PSA) 10ml/kg, from the initiation of spinal anesthesia.

Treatment:

Other: Crystalloid

Colloid

Active Comparator group

Description:

Patients will receive rapid co-load of 6% volulyte (HES in acetated electrolyte) 10ml/kg, from the initiation of spinal anesthesia.

Treatment:

Other: Colloid