CsA vs MMC for Preventing Pterygium Recurrence

Benha University

Status: Completed

Conditions: Pterygium of the Conjunctiva and Cornea; Pterygium

Treatments: Procedure: Excision of the pterygium; Drug: Intra-operative application of MMC; Drug: Post-operative application of CsA

Study type: Interventional

Funder types: Other

Identifiers

NCT06944132

Benha University

CsA vs MMC for pterygium

Details and patient eligibility

About

aimed to compare the efficacy and safety of topical cyclosporin A (CsA) versus mitomycin C (MMC) as adjunctive therapies in preventing pterygium recurrence after surgical excision.

Full description

A total of 40 eyes from 40 patients undergoing pterygium surgery were randomized into two groups: Group A received topical cyclosporin A, while Group B was treated with topical mitomycin C. Ocular surface inflammation scores, recurrence rates, patient-reported symptoms, and adverse effects were assessed at baseline and during follow-up at 6 months postoperatively.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 years or older.
• Diagnosed with primary pterygium extending at least 1 mm onto the cornea.
• No prior history of pterygium surgery in the affected eye.

Exclusion criteria

• History of ocular surface diseases such as dry eye or Sjögren's syndrome.
• Active ocular infection.
• Known hypersensitivity to CsA or MMC.
• Systemic conditions requiring immunosuppressive therapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Group A (CsA Group)

Active Comparator group

Description:

Patients received topical cyclosporin A (0.05%) twice daily for three months postoperatively.

Treatment:

Drug: Post-operative application of CsA

Procedure: Excision of the pterygium

Group B (MMC Group)

Active Comparator group

Description:

Patients received a single intraoperative application of mitomycin C (0.02%) for two minutes during surgery

Treatment:

Drug: Intra-operative application of MMC

Procedure: Excision of the pterygium