CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan

Adnexus

Status and phase

Unknown

Phase 2

Conditions

Recurrent Glioblastoma Multiforme

Brain and Central Nervous System Tumors

Treatments

Drug: irinotecan hydrochloride

Drug: CT-322

Study type

Interventional

Funder types

Industry

Identifiers

NCT00562419

CT-322.002

Details and patient eligibility

About

RATIONALE: CT-322 may stop the growth of glioblastoma multiforme by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving CT-322 together with irinotecan may kill more tumor cells.

PURPOSE: This phase 2 trial is studying the side effects, tolerability, and efficacy of CT-322 when given alone and in combination with irinotecan to patients with glioblastoma multiforme.

Enrollment

72 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS

Histologically confirmed diagnosis of recurrent/progressive GBM presenting in first, second, or third relapse (progression following anti-cancer therapy other than surgery)
Bidimensionally measurable recurrent or residual primary disease on contrast-enhanced MRI

PATIENT CHARACTERISTICS

Age:

• 18 and over

Hematopoietic:

ANC ≥ 1,500/mL
Platelets ≥ 100,000/mL
Hemoglobin ≥ 9.0g/dL

Hepatic:

AST and ALT ≤ 1.5 x ULN
Bilirubin ≤ 1.5 x ULN

Coagulation:

• INR < 1.5 or PT within normal limits; and PTT within normal limits

Renal:

Creatinine ≤ 1.5 x ULN; Urine protein/creatinine ratio ≤ 1

Cardiovascular

2-dimensional echocardiogram or cardiac multigated acquisition (MUGA) scan demonstrating left ventricular ejection fraction within the institutional normal range.
No coronary artery bypass graft, angioplasty, vascular stenting, myocardial infarction, unstable angina, congestive heart failure within the preceding 12 months.
No thrombotic or embolic cerebrovascular accident, including transient ischemic attacks within the past 12 months and no conditions that would not permit the safe discontinuation of specified anti-platelet medications
No intraparenchymal CNS hemorrhage, except for Grade 1 intraparenchymal hemorrhage in the immediate post-operative period or Grade 1 intraparenchymal hemorrhage that has been stable or improved

Immunologic:

• Not known to have human immunodeficiency virus infection (HIV) or active hepatitis B or C virus infection

Other:

Negative pregnancy test within 72 hours prior to drug administration
Not pregnant or breast feeding
Fertile patients must agree to use effective methods of birth control and must agree to do so until at least 4 weeks after the last dose of drug administration
No serious non-healing wound, ulcer or bone fracture or recent significant traumatic injury (within 4 weeks)
Have ability to understand and sign an informed consent document
Be willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures
No other malignancy within the past 3 years, except for basal cell skin cancer, cervical carcinoma in situ, or other primary malignancy that is not currently clinically significant or does not require active intervention
No prior grade 3 or greater toxicity to irinotecan
No other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that could increase the risks associated with study participation or study drug administration or could interfere with the interpretation of the study results and would make the patient inappropriate for study entry

PRIOR CONCURRENT THERAPY:

Biologic therapy:

See Disease Characteristics
At least 4 weeks between prior biological or immunotherapy and recovered

Chemotherapy:

See Disease Characteristics
At least 4 weeks since prior chemotherapy and recovered (6 weeks for nitrosoureas), unless there is unequivocal evidence of tumor progression

Radiotherapy:

• At least 12 weeks from completion of standard, daily radiotherapy and recovered, unless any of the following occurs:

New area of enhancement on MRI that is outside the radiotherapy field
Biopsy-proven recurrent tumor
Radiographic evidence of progressive tumor on 2 consecutive scans taken ≥ 4 weeks apart

Surgery

At least 4 weeks since major surgery, open biopsy or significant traumatic injury and recovered
At least 1 week since other prior biopsy

Other:

Not concurrently enrolled in another therapeutic clinical trial involving ongoing therapy
No prior treatment with VEGF or VEGFR inhibitors or vascular targeting/disrupting agents
No prior CT-322 therapy
No prior failure of irinotecan therapy
No prior treatment with stereotactic radiosurgery, brachytherapy, or a surgically created resection cavity to support other anatomically localized therapies
No severe or uncontrolled medical disease (uncontrolled diabetes, hypertension, serious infection > CTCAE grade 2, significant bleeding or platelet dysfunction, gastrointestinal bleed)