CT-angiographic Follow up of Patients That Underwent Coronary Bypass Surgery Between 1993-1997

Örebro County Council

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Procedure: No touch technique; Procedure: Conventional technique

Study type: Interventional

Funder types: Other

Identifiers

NCT01686100

102841

Details and patient eligibility

About

Coronary artery surgery (CABG) is necessary to improve blood circulation in many patients with coronary artery disease. This is done by using alternative blood vessels (grafts) to bypass the stenosed coronary arteries. In CABG, vein grafts are traditionally used where surrounding tissue is removed, this may damage the vessel and influence its patency.

The "no-touch" technique was developed by Professor Domingos Souza at the Department of Cardiovascular and Thoracic Surgery, Örebro University Hospital. This technique includes taking out the vein with its surrounding tissue and by this way the vessel is less damaged. The first two follow ups have shown that no-touch grafts had better patency than conventionally extracted graft at 18 months and 8.5 years.

This long term follow up is a continuation of the randomized trial started in 1993 where the patency and incidence of stenoses in the no touch and conventional vein grafts has been studied.

Enrollment: 52 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. First time coronary artery bypass grafting with either conventional or no touch vein grafts performed by Dr.Souza between 1993-1997.
2. Included in the previous follow up studies
3. Signed and dated consent.

Exclusion criteria

1. Allergy to contrast
2. Renal failure
3. Uncontrolled diabetes
4. Unable to implement the study according to protocol -

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups

No touch vein grafts

Active Comparator group

Description:

The grafts were harvested with there surrounding tissues.

Treatment:

Procedure: No touch technique

Conventional vein grafts.

Active Comparator group

Description:

The grafts were stripped from surrounding tissue.

Treatment:

Procedure: Conventional technique