CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis (CT-DEFINE)

Technische Universität Dresden

Status: Completed

Conditions: Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT00463281

23211204

Details and patient eligibility

About

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that

1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies
2. patients with a "tissue window" suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ischemic anterior circulation stroke
• last seen normal < 12 hours
• stroke severity => 3 on the National Institute of Health Stroke Scale
• multimodal CT stroke protocol performed
• informed consent obtained

Exclusion criteria

• premorbid modified Rankin Scale score > 3
• contraindications to contrast media application
• pregnancy or breast feeding
• subacute stroke > 50 % of MCA territory
• CT evidence of non-vascular cause of stroke symptoms