CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight

F

Free University of Brussels (ULB)

Status

Completed

Conditions

Healthy

Treatments

Radiation: Low-dose chest CT scans

Study type

Observational

Funder types

Other

Identifiers

NCT02611947
P2010/175

Details and patient eligibility

About

Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.

Full description

87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests: On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions. Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values). CT indexes were compared with gender, height and weight.

Enrollment

87 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Never smoked.
  • No respiratory infection in the 4 weeks before the begin of the study.
  • No history of pulmonary resection.
  • No active malignancy or malignancy of any organ system within the past 5 years.

Exclusion criteria

no exclusion criteria

Trial design

87 participants in 1 patient group

Healthy Volunteers
Description:
Inclusion criteria: Aged 18 or more. Never smoked. No respiratory infection in the 4 weeks before the begin of the study. No history of pulmonary resection. No active malignancy or malignancy of any organ system within the past 5 years.
Treatment:
Radiation: Low-dose chest CT scans

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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