CT Perfusion Changes in GI Cancer During Adenosine Vasodilation Test

University of Copenhagen

Status: Completed

Conditions: Gastric Cancer; Esophageal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02074124

H-3-2012-067 (Other Identifier)

Details and patient eligibility

About

The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.

Enrollment: 15 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Tumour larger than 1.5 cm on diagnostic CT
• Normal serum creatinine
• Age above 18
• Informed written and oral consent.

Exclusion criteria

• Contrast allergy or contrast induced nephropathy
• BMI > 40
• Asthma or Chronic Obstructive Lung Disease
• Heart failure (NYHA III+)
• Heart conduction disorder
• Atrial fibrillation
• 2nd/3rd Heart block
• Long QT syndrome
• Wolf Parkinson White Syndrome
• Moderate / severe aortic stenosis
• Haemodynamic contraindications for adenosine, systolic pressure below 90

Trial design

15 participants in 2 patient groups

Adenosine Vasodilation test

Description:

Group scanned with CT perfusion during adenosine vasodilation test.

Reference group

Description:

Group scanned twice without adenosine vasodilation test for a reference. No randomization.