CT Perfusion Images in Assessing Treatment Response in Patients With Pancreatic Cancer

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University of Washington

Status

Terminated

Conditions

Pancreatic Ductal Adenocarcinoma

Treatments

Diagnostic Test: Computed Tomography Perfusion Imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT03012282
NCI-2016-01780 (Registry Identifier)
RG3017007 (Other Identifier)
9625 (Other Identifier)

Details and patient eligibility

About

This pilot clinical trial studies how well computed tomography (CT) perfusion images work in assessing treatment response in patients with pancreatic cancer. Analyzing specific measurements on the CT perfusion images may help doctors better determine how a tumor responds to chemotherapy and/or radiation therapy and may help guide treatment for patients with pancreatic cancer.

Full description

OUTLINE: Patients undergo CT perfusion sequence during the first 40 seconds of the baseline standard of care CT scan and during follow-up CT scans at 2 and possibly 4 months after chemotherapy, at 4-6 weeks after radiation therapy, or prior to definitive surgery. After completion of the study, patients are followed up periodically for 2 years.

Enrollment

70 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Signed informed consent form
  • A diagnosis of pancreatic ductal adenocarcinoma

Exclusion criteria

  • Patients unable to provide informed consent
  • Women who are pregnant or intending to become pregnant during the study
  • Patients with body mass index greater than 40 kg/m^2
  • History of severe allergic-like reaction to iodinated contrast media

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

70 participants in 1 patient group

Diagnostic (CT perfusion sequence)
Experimental group
Description:
Patients undergo CT perfusion sequence during the first 40 seconds of the baseline standard of care CT scan and during follow-up CT scans at 2 and possibly 4 months after chemotherapy, at 4-6 weeks after radiation therapy, or prior to definitive surgery.
Treatment:
Diagnostic Test: Computed Tomography Perfusion Imaging

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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