CT Perfusion Images in Assessing Treatment Response in Patients With Pancreatic Cancer

University of Washington

Status: Terminated

Conditions: Pancreatic Ductal Adenocarcinoma

Treatments: Diagnostic Test: Computed Tomography Perfusion Imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT03012282

NCI-2016-01780 (Registry Identifier)

RG3017007 (Other Identifier)

9625 (Other Identifier)

Details and patient eligibility

About

This pilot clinical trial studies how well computed tomography (CT) perfusion images work in assessing treatment response in patients with pancreatic cancer. Analyzing specific measurements on the CT perfusion images may help doctors better determine how a tumor responds to chemotherapy and/or radiation therapy and may help guide treatment for patients with pancreatic cancer.

Full description

OUTLINE:

Patients undergo CT perfusion sequence during the first 40 seconds of the baseline standard of care CT scan and during follow-up CT scans at 2 and possibly 4 months after chemotherapy, at 4-6 weeks after radiation therapy, or prior to definitive surgery.

After completion of the study, patients are followed up periodically for 2 years.

Enrollment: 70 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent form
• A diagnosis of pancreatic ductal adenocarcinoma

Exclusion criteria

• Patients unable to provide informed consent
• Women who are pregnant or intending to become pregnant during the study
• Patients with body mass index greater than 40 kg/m^2
• History of severe allergic-like reaction to iodinated contrast media

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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70 participants in 1 patient group

Diagnostic (CT perfusion sequence)

Experimental group

Description:

Patients undergo CT perfusion sequence during the first 40 seconds of the baseline standard of care CT scan and during follow-up CT scans at 2 and possibly 4 months after chemotherapy, at 4-6 weeks after radiation therapy, or prior to definitive surgery.

Treatment:

Diagnostic Test: Computed Tomography Perfusion Imaging