CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms

Francesco De Cobelli

Status: Completed

Conditions: Pancreatic Neuroendocrine Tumor

Treatments: Other: CT radiomic feature evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT03967951

panNEN

Details and patient eligibility

About

The aim of this study is to quantify inter-observer variability in delineating pancreatic neuroendocrine neoplasm (PanNEN) on Computerized Tomography (CT) images and its impact on radiomic features (RF), subsequently to this determination, to use CT texture analysis to predict, histological characteristics of PanNEN on CT scans.

Full description

CT imaging is the most widely used modality for studying radiomic features due to its ability to assess tissue density, shape, texture and size before, during and after therapy. To the best of the investigator's knowledge, the impact of inter-observer delineation variability on the reliability of CT RF for PanNEN patients, including Hounsfield unit (HU) values-, shape-, and texture-based features, has not yet been assessed. One this has been determined, an additional evaluation will be conducted to correlate the morphologically observed images with their histopathological characteristics.

The ultimate potential objective of this research is to identify and predict characteristics of aggressiveness of PanNEN in CT scans.

Enrollment: 70 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years of age
• pancreatic neuroendocrine neoplasm with intervention and biopsy
• availability of pre-operatory CT scan with or without IV contrast agent- inInstitution from 2009-2017

Exclusion criteria

• pregnant women