ctDNA and MRI Parameters in Head and Neck Cancer

Franziska Eckert

Status: Not yet enrolling

Conditions: Carcinoma, Squamous; Head and Neck Neoplasms

Treatments: Other: Blood draw, MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT06215612

1452/2023

Details and patient eligibility

About

Patients undergoing primary radiochhemotherapy for locally advanced head and neck squamous cell carcinomas are included in this study. In addition to standard of care treatment patients will undergo addiational blood draws and MR imaging studies. Circulating cell free tumor DNA will be analysed in the blood samples. BIological data, imaging data and clinical data (such as patient and tumor characteristics, oncologic outcome, side effects) will be analysed in a biomathematical modelling approach.

Enrollment: 50 estimated patients

Sex: All

Ages: 19 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Squamous cell carcinoma head and neck
• Planned primary platinum based radiochemotherapy
• ECOG 0-2

Exclusion criteria

• Palliative therapy intent
• Not MR eligible

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)