CTEPH in Patients With Prior Pulmonary Embolism and Risk Score Validation (CTEPH-SOLUTION)

iPHNET (italian Pulmonary Hypertension NETwork)

Status: Unknown

Conditions: Pulmonary Embolism; Chronic Thromboembolic Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT04681014

CTEPH-SOLUTION

Details and patient eligibility

About

CTEPH-SOLUTION aims to create a risk score for the early detection of Chronic Thrombo-Embolic Pulmonary Hypertension (CTEPH) among patients with previous pulmonary embolism.

The risk score, created on retrospective data, will be validated on newly diagnosed pulmonary embolism patients.

Full description

CTEPH-SOLUTION is a multicenter observational cross-sectional and prospective study in patients with a prior and new diagnosis of pulmonary embolism.

Patients with prior pulmonary embolism will be screened at baseline with doppler echocardiography: an estimated sPAP ≥ 40 mmHg will be the indication for pulmonary hypertension detection. After 24 months from baseline, patients will be followed-up for CTEPH detection. CTEPH diagnosis will be carried out according to the current ESC/ERS guidelines.

Incident (pulmonary embolism episode at least three months before the baseline) and prevalent (pulmonary embolism episode) patients will be enrolled.

Enrollment: 1,218 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 at baseline evaluation
• Diagnosis of prior (> 30 days from pulmonary embolism onset) or new-onset pulmonary embolism, according to the ESC guidelines on the diagnosis and management of acute pulmonary embolism

Exclusion criteria

• patients without pulmonary embolism diagnosis