CTPVB for Hepatectomy

Cui Xulei

Status: Completed

Conditions: Hepatectomy; Pain Management; Paravertebral Block

Treatments: Drug: Patient-controlled analgesia with morphine; Procedure: Continuous Paravertebral block with ropivacaine; Procedure: Continuous Paravertebral "block" with saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03990922

PVB_H

Details and patient eligibility

About

Moderate to severe postoperative pain often influence patients quality of recovery after hepatectomy. Systemic opioids given with patient-controlled analgesia has been used after hepatectomy in many medical center, but the analgesic effect can be limited and undesirable side effects may bring about negative effects on patients recovery. Regional block has been proved to improve patients postoperative recovery in many kinds of surgeries.

The investigators therefore designed a prospective, randomized, subject and assessor blinded, parallel-group, placebo controlled study to test the hypothesis that continuous right thoracic paravertebral block increase patients quality of recovery score on the 7th postoperative day after hepatectomy in patients receiving i.v. patient-controlled analgesia (PCA) with morphine.

Enrollment: 76 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo hepatectomy with J-shape subcostal incision
• Informed consent

Exclusion criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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76 participants in 2 patient groups, including a placebo group

CTPVB with ropivocaine

Experimental group

Description:

Continuous Paravertebral block with ropivacaine and Patient-controlled analgesia with morphine

Treatment:

Procedure: Continuous Paravertebral block with ropivacaine

Drug: Patient-controlled analgesia with morphine

CTPVB with saline

Placebo Comparator group

Description:

Continuous Paravertebral block with saline and Patient-controlled analgesia with morphine

Treatment:

Procedure: Continuous Paravertebral "block" with saline

Drug: Patient-controlled analgesia with morphine