Culturally-Targeted COVID-19 Communication and SARS-CoV-2 Antibody Testing Evaluation and Uptake

Michigan State University

Status: Completed

Conditions: SARS-CoV2 Infection

Treatments: Behavioral: General SARS-CoV-2 Communication; Behavioral: Culturally Targeted SARS-CoV-2 Communication

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04957082

MSUSeronet1

U01CA260469 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This disparities-focused study seeks to evaluate communication strategies for better encouraging understanding and uptake of salivary SARS-CoV-2 antibody testing among African Americans residing in Flint, Michigan. This iteration will consider individuals recruited from the Flint Registry and assess willingness to participate in a drive-up saliva sample collection taking place at a central location in Flint, Michigan.

Full description

African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. Addressing these disparities may be aided by SARS-CoV-2 antibody testing. However, African Americans may be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism. This study seeks to evaluate communication strategies for better encouraging understanding and uptake of salivary SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be more receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner. Our clinical trial aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents' antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally-targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing. In collaboration with clinical and community partners, we have prepared and will evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry - a highly visible local health resource exchange. We will furnish an opportunity to engage salivary antibody screening and measure willingness to participate. In this study iteration, we will consider willingness to participate in a drive-up saliva sample collection that is taking place at a central location in Flint, Michigan.

Enrollment: 666 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• African American or White, 18 or older, and enrolled in the Flint Registry

Exclusion criteria

• All who do not meet inclusion criteria.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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666 participants in 3 patient groups

White Flint Registry: General

Active Comparator group

Description:

White participants receive "general consumption" video information about SARS-CoV-2 antibody testing.

Treatment:

Behavioral: General SARS-CoV-2 Communication

African American Registry: General

Active Comparator group

Description:

African American participants receive "general consumption" video information about SARS-CoV-2 antibody testing.

Treatment:

Behavioral: General SARS-CoV-2 Communication

African American Registry: Culturally Targeted

Experimental group

Description:

African American participants receive culturally targeted video information about SARS-CoV-2 antibody testing.

Treatment:

Behavioral: Culturally Targeted SARS-CoV-2 Communication