Curcumin Gel On Radiation Induced Oral Mucositis

University of Baghdad

Status: Completed

Conditions: Radiation-Induced Mucositis; Head and Neck Cancer

Treatments: Drug: Curcumin Gel; Drug: Standard Preparation

Study type: Interventional

Funder types: Other

Identifiers

NCT05982197

705722

Details and patient eligibility

About

The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of EGFs and IL8.

Researchers will compare between curcumin group and standard treatment group.

Enrollment: 40 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients above 16 years having histopathologically confirmed cancer in head and neck region who planned to have radiation with head and neck mask.
• Scheduled for 6-8 weeks of radiotherapy with 60-70Gy radiation (200cgy/fraction for 5 days/week).

Exclusion criteria

• patient with hodgkin lymphoma.
• Any allergy to curcumin or other condiments.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Curcuma longa oral gel group

Active Comparator group

Treatment:

Drug: Curcumin Gel

Standard treatment group

Active Comparator group

Treatment:

Drug: Standard Preparation