Customized Multiple Orbital Wall Decompression for Sight-threatening Graves's Ophthalmopathy

Sun Yat-sen University

Status

Enrolling

Conditions

Thyroid Eye Disease

Treatments

Procedure: Modified multiple orbital wall decompression

Study type

Observational

Funder types

Other

Identifiers

NCT05627401

SYSKY-2022-349-01

Details and patient eligibility

About

Graves' orbitopathy (GO) is an disfiguring and disabling autoimmune condition. Sight-threatening GO is an most severe form and occurs in about 5% of patients with Graves' disease. It can cause blurred vision, color vision and vision function damage, and affects the quality of life. The goal of this retrospective cohort study is to propose a customized orbital decompression algorithm for patients with sight-threatening Graves'ophthalmopathy and to explore the therapeutic effect of customized orbital decompression in sight-threatening patients.

Enrollment

78 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Sight-threatening patients undergoing interdisciplinary discussion and orbital decompression operation.
The sight-threatening GO refer to those with DON, exposure keratitis or corneal breakdown.
DON was diagnosed according to the following clinical findings including optic nerve head edema, visual field defect, impaired color vision, afferent pupil defect, retinal folds, radiologic evidence of apical optic nerve compression or globe subluxation.
Diagnosis of exposure keratitis or corneal breakdown was made based on physical exam signs, e.g. microepithelial defects, abrasion or ulcer. A minimum follow-up of 12 months was required for inclusion.

Exclusion criteria

Patients were excluded if exophthalmos, rather than acute visual loss, was the indication for surgery.
Cases with a history of previous ocular surgery, glaucoma, and visual defects from other ocular conditions were excluded from the study.