Cutaneous Microcirculation and Nervous Sensitivity in Psoriasis (MicroPso)

Civil Hospices of Lyon

Status: Completed

Conditions: Psoriasis

Treatments: Other: Laser Doppler recording; Other: ppi water iontophoresis; Other: Sodium Nitroprussiate iontophoresis; Other: Acetylcholine iontophoresis

Study type: Interventional

Funder types: Other

Identifiers

NCT02652065

69HCL15_0425

Details and patient eligibility

About

Psoriasis is a chronic inflammatory cutaneous disease, affecting 3% of the French population. Among psoriatic patients, 80% feel pain or cutaneous discomfort related to their pathology.

Neurogenic inflammation's role in psoriasis has recently been put forward by a study showing that TRPV1 ion channels are necessary to establish psoriasiform inflammation in mice.

The investigators hypothesize that there is a link between cutaneous sensory neuropathies and altered cutaneous microcirculation during psoriasis.

In order to test this hypothesis, local vasodilators will be delivered to patients by iontophoresis and their skin blood flow in response to these molecules will be followed by laser Doppler recordings. Two recordings will be performed for each patient, both on a psoriasis plaque and on uninvolved skin, in order for the patient to be his own internal control.

Enrollment: 20 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type I psoriasis
• Psoriasis plaques on the patient's back

Exclusion criteria

• BMI > 25
• Diabetic patient
• Arteriovenous disease history
• Ongoing anti-inflammatory treatment
• Major cardiovascular history (<3 months)
• Hypertension
• Topical treatment on the back skin (<7 days)
• Systemic treatment (steroids, methotrexate, retinoids, cyclosporine) or phototherapy (<1 month)
• Pregnant women
• Subject within exclusion period following a previous or ongoing biomedical study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Healthy skin

Active Comparator group

Description:

Local vasodilators (acetylcholine, sodium nitroprussiate and ppi water as control) will be delivered to patients by iontophoresis on healthy skin. The skin blood flow in response to these molecules will be followed by laser Doppler recordings.

Treatment:

Other: Sodium Nitroprussiate iontophoresis

Other: Acetylcholine iontophoresis

Other: ppi water iontophoresis

Other: Laser Doppler recording

Psoriasis plaque

Experimental group

Description:

Local vasodilators (acetylcholine, sodium nitroprussiate and ppi water as control) will be delivered to patients by iontophoresis on a psoriasis plaque (on the patient's back). The skin blood flow in response to these molecules will be followed by laser Doppler recordings.

Treatment:

Other: Sodium Nitroprussiate iontophoresis

Other: Acetylcholine iontophoresis

Other: ppi water iontophoresis

Other: Laser Doppler recording