Cutibacterium Acnes in Bone and Joint Infections (CaBJI)

CHU de Reims

Status: Unknown

Conditions: Cutibacterium Acnes; Prosthesis and Bone Infections

Study type: Observational

Funder types: Other

Identifiers

NCT03950063

PA18027

Details and patient eligibility

About

Prosthetic Joint Infections (PJIs) are increasing with the use of orthopedic devices on an ageing population. Cutibacterium acnes is a commensal organism that plays an important role in the ecosystem healthy human skin, yet this species is also recognized as a pathogen in foreign body infection: endocarditis, prostatitis and specifically in PJIs. C. acnes is able to escape the immune system. This phenomenon could reflect two bacterial behavior: the bacterial internalization by host cells and the biofilm formation.

Full description

The aim of the study is to evaluate specific pathogenicity factors (ability to internalize bone cells and ability to form a biofilm) of bacteria derived from clinical strains of C. acnes isolated from bone infections on orthopedic material.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• bone infection with C. acnes,
• isolation of the strain,
• presence of a single species,
• conservation of a viable strain,
• patients over 18 years

Trial design

50 participants in 1 patient group

Patients with Cutibacterium acnes bone infections

Description:

Patients with Cutibacterium acnes orthopedic material infections