CVL Risk After Severe Glaucoma Surgery

Yonsei University Health System (YUHS)

Status: Active, not recruiting

Conditions: Severe-stage Glaucoma (Mean Deviation ≤ -20 dB)

Study type: Observational

Funder types: Other

Identifiers

NCT07237555

3-2024-0364

Details and patient eligibility

About

This retrospective cohort study analyzes risk factors for central visual loss (CVL) after severe-stage glaucoma surgery. The primary hypothesis is that 1) visual prognosis is determined primarily by early postoperative intraocular pressure (IOP) stability rather than surgical choice, and 2) the nature of risk (hypotony vs hypertension) is modified by baseline visual reserve. We analyzed outcomes in 523 patients with severe-stage glaucoma who underwent trabeculectomy or Ahmed glaucoma valve (AGV) implantation, focusing on the dichotomous risk profile stratified by baseline visual acuity.

Enrollment: 523 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patients who underwent trabeculectomy or Ahmed glaucoma valve implantation at Yonsei Medical Center between January 2005 and October 2024.

  2. Glaucoma patients who underwent static quantitative perimetry (visual field test) before and after surgery.

  3. Patients with a preoperative Mean Deviation (MD) of ≤ -20 dB.

Exclusion criteria

• 1. Patients who were unable to undergo visual field testing due to poor preoperative visual acuity.

  2. Patients with central visual field defects caused by retinal or neurological diseases other than glaucoma.

  3. Patients with false-positive or false-negative responses ≥33% on visual field testing.

Trial design

523 participants in 2 patient groups

Group 1

Description:

231 eyes that underwent trabeculectomy for severe-stage glaucoma

Group 2

Description:

292 eyes that underwent Ahmed glaucoma valve implantation for severe-stage glaucoma