Cyanoacrylate Tissue Adhesives Versus Silk Suture at the Palatal Donor Site of Sub Epithelial Connective Tissue Graft

Cairo University (CU)

Status: Unknown

Conditions: The Effect of Local Aplication of Cayanoacrylate Tissue Adhesives on Improving the Healing

Treatments: Procedure: Silk suture; Procedure: Cayanoacrylate tissue adhesives

Study type: Interventional

Funder types: Other

Identifiers

NCT04780360

567

Details and patient eligibility

About

Subepithelial connective tissue grafts (CTG) are considered the gold standard procedure with proven clinical success when it comes to gingival augmentation aims to to improve periodontal health, which can enhance the long-term prognosis of teeth by obtaining soft tissue coverage of exposed root surfaces and/or augmentation the dimensions of gingival tissue. The procedure require harvesting tissue from a the palate, which increases the complexity of the procedure and patient discomfort. Complications after harvesting a graft would be pain, inflammation, bleeding, flap necrosis and infection in the donor site.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with mucogingival defects scheduled for sub epithelial connective tissue graft
• Age at least 18 years.
• Not having any systemic disease that could compromise wound healing
• No periodontal surgery on the experimental sites.
• No smoking,
• No pregnancy or lactation

Exclusion criteria

• Patients with coagulation disorders
• patients on corticosteroids, with uncontrolled diabetes, or with any systemic disease that precluded periodontal surgery
• patients with a history of contact dermatitis to formaldehyde
• Loss of maxillary premolars and molars
• Medications or antibiotics used in the previous 6 months
• Pregnancy or lactation
• Smoking

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Cayanoacrylate tissue adhesives

Experimental group

Description:

thin layers of high viscosity blend of n-butyl and 2-octyl cayanoacrylate tissue adhesive will be applied and rinsed with saline at least three times with interval of at least 30 seconds

Treatment:

Procedure: Cayanoacrylate tissue adhesives

Silk suture material

Active Comparator group

Description:

interrupted knots

Treatment:

Procedure: Silk suture