CyberKnife Radiosurgery for Locally Recurrent Prostate CA

CyberKnife Centers of San Diego

Status and phase

Unknown

Phase 2

Conditions

Recurrent Prostate Cancer

Treatments

Radiation: CyberKnife Radiosurgery

Study type

Interventional

Funder types

Other

Identifiers

NCT00851916

CK Recurrent Prostate SD

Details and patient eligibility

About

The purpose of this study is to scientifically evaluate the effects (good and bad) of a new type of radiation treatment in patients with locally recurrent prostate cancer after prior radiotherapy. The treatment is known as prostate radiosurgery, and is distinguished from traditional radiotherapy by the application of smaller, more precisely controlled margins around the area targeted for full dose radiation, and far fewer treatments, using a much larger dose per treatment.

This research is being done to see what advantages, if any, prostate radiosurgery may have over other salvage treatment methods, including brachytherapy, cryosurgery, high intensity focused ultrasound (HIFU), hormonal therapy and radical prostatectomy.

Enrollment

20 estimated patients

Sex

Male

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed recurrent adenocarcinoma of the prostate, clinical stage T1 - T3 (AJCC 6th Edition, see Appendix II), NX/N0, M0, following prior prostate radiotherapy.
Karnofsky performance status >80.
Greater than 5 year life expectancy
Greater than 2 years since the original course of radiotherapy.
Absence of distant metastases by radiologic or pathologic assessment.
Absence of lymph node involvement by radiologic or pathologic assessment.
Patients must sign a study-specific informed consent form prior to study entry.

Exclusion criteria

Stage T4 disease (AJCC 6th Edition, see Appendix II).
Less than 2 years since the original course of radiotherapy.
Lymph node involvement (N1).
Evidence of distant metastases (M1).
Radical surgery for carcinoma of the prostate
Previous or concurrent cancers other than basal, in situ, or squamous cell skin cancers unless disease-free for ≥ 5 years.
Major medical or psychiatric illness, which in the investigator's opinion, would prevent completion of treatment and would interfere with follow-up.
History of inflammatory bowel disease
Late GI or GU Morbidity > Grade 1 from the prior course of radiotherapy