Cycling Exercise in Mechanical Ventilation

University Hospital Ostrava

Status: Completed

Conditions: Mechanical Ventilation Complication; Muscle Weakness

Treatments: Other: Conventional Physiotherapy; Other: Cycling Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03581760

MH CZ - DRO-FNOs/2017 (Other Grant/Funding Number)

KARIM-08-Motomed

Details and patient eligibility

About

Prolonged critical illness renders survivors with increased long-term morbidity associated with high healthcare costs. Muscle weakness and fatigue are reported as the main contributors to long-term poor functional outcomes. Emerging evidence for early mobilisation demonstrates reduction in the number of ventilator days and hospital length of stay. It has been demonstrated that daytime motoring (passive and active) can improve functional capacity in intensive care patients. The aim of the proposed study is to evaluate the effect of cycling exercise in patients on mechanical ventilation appointed to weaning process.

Full description

This prospective randomized study is being performed at the Department of Anesthesiology, Resuscitation and Intensive Care (CARIM) of the University Hospital Ostrava.

All mechanically ventilated patients are followed. At the time of weaning initiation, the randomization into two groups (the study (cycling) and control group) is performed. The physiotherapy will be carried out twice a day in both groups according to the mobility protocol. The cycling exercise is performed only in the study group, once a day. Before a patient is released from the ICU, a cycling test, dynamometry test will be performed on both groups.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• ICU admission
• Mechanically ventilated for more than 5 days
• Indications for starting weaning
• Informed consent for participation

Exclusion criteria

• Inability to use cycling exercise: trauma or operation of lower limbs, pelvis, open abdomen, non-cooperation (qualitative and quantitative disturbance of consciousness)
• Encephalopathy (ischemic, traumatic)
• Extreme obesity (body mass index ≥ 40)
• Anticipated survival time ≤ 7 days
• Patient height ≤ 1.5 m
• More than 48 hours of mechanical ventilation outside of the department

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Cycling Exercise

Experimental group

Description:

Patients randomized into this arm will undergo cycling exercise once a day while on mechanical ventilation at intensive care unit.

Treatment:

Other: Cycling Exercise

Other: Conventional Physiotherapy

Conventional Physiotherapy

Active Comparator group

Description:

Patients randomized into this arm will undergo conventional physiotherapy twice a day while on mechanical ventilation at intensive care unit.

Treatment:

Other: Conventional Physiotherapy