Cyclophotocoagulation in Glaucoma

Laval University

Status: Completed

Conditions: Glaucoma

Treatments: Procedure: Cyclophotocoagulation protocol; Procedure: Conventional cyclophotocoagulation; Procedure: Modified cyclophotocoagulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02875158

2015-2212

Details and patient eligibility

About

Transscleral cyclophotocoagulation of the ciliary body is an effective technique to reduce intraocular pressure in case of glaucoma. Due to concerns over complications, the main indications for this second-line treatment are refractory glaucoma medication / surgery and low visual prognosis. The 2000 milliwatts (mW) for 2 seconds settings are used by the majority of researchers and clinicians according to the published literature. Some have proposed using 1250 mW for 4 seconds to improve the use of this medical procedure.

The aim of this study is to determine how different parameters affect the efficacy of the treatment. This is a prospective double-blinded randomized controlled trial comparing two groups, the experimental group using 1250 mW for 4 seconds and the control group using 2000 mW for 2 seconds.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with poorly controlled high pressure glaucoma
• Cyclophotocoagulation necessary to prevent visual loss
• Cyclophotocoagulation necessary to prevent or to reduce ocular discomfort

Exclusion criteria

• Patient has already undergone a cyclophotocoagulation or cryotherapy treatment in the same eye for glaucoma
• Patients receiving concomitant treatment the same day as the intervention
• Patient not able to follow the prescribed post-operative treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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44 participants in 2 patient groups

Diode laser using conventional settings

Active Comparator group

Description:

The cyclophotocoagulation protocol is used with the conventional cyclophotocoagulation settings of 2000 mW for 2 seconds.

Treatment:

Procedure: Conventional cyclophotocoagulation

Procedure: Cyclophotocoagulation protocol

Diode laser using modified settings

Experimental group

Description:

The cyclophotocoagulation protocol is used with the modified cyclophotocoagulation settings of 1250 mW for 4 seconds.

Treatment:

Procedure: Modified cyclophotocoagulation

Procedure: Cyclophotocoagulation protocol