Cyclosporine A in Cardiac Arrest (CYRUS)

Civil Hospices of Lyon

Status and phase: Completed; Phase 3

Conditions: Non Shockable Out of Hospital Cardiac Arrest

Treatments: Drug: Cyclosporine A; Procedure: cardio-pulmonary resuscitation

Study type: Interventional

Funder types: Other

Identifiers

NCT01595958

2009-015725-37 (EudraCT Number)

2009.571

Details and patient eligibility

About

The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.

Enrollment: 796 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Witnessed out-of-hospital cardiac arrest
• Non shockable cardiac rhythm

Exclusion criteria

• Evidence of trauma
• Evidence of pregnancy
• Duration of no flow more than 30 minutes
• Rapidly fatal underlying disease
• Allergy to cyclosporin A

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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796 participants in 2 patient groups

Cyclosporine A

Experimental group

Description:

Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation

Treatment:

Procedure: cardio-pulmonary resuscitation

Drug: Cyclosporine A

Control

Active Comparator group

Description:

usual care of cardiac arrest

Treatment:

Procedure: cardio-pulmonary resuscitation