Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis

Souzy Kamal

Status and phase: Completed; Phase 4

Conditions: Periodontitis Chronic Generalized Moderate

Treatments: Drug: Cymbopogon citratus (lemongrass) oil gel

Study type: Interventional

Funder types: Other

Identifiers

NCT05241509

Lemon grass oil

Details and patient eligibility

About

Background: Phytotherapeutics is widely used nowadays as an adjunct to scaling and root planing (SRP) to modulate inflammatory host response and eradicate microbes. Matrix metalloproteinase-8 (MMP-8) is associated with the onset of inflammation and considered an indicative biomarker to the severity of inflammatory response. Since MMP-8 can be used as a predictive biomarker for treatment response; our research aimed to investigate clinically the effectiveness of intra-pocket application of Cymbopogon citratus (lemongrass oil) gel and biochemically on MMP-8 levels in gingival crevicular fluid (GCF) of stage II periodontitis patients.

Methods: A randomized controlled clinical trial was conducted on forty patients with stage II periodontitis, divided equally into two groups. Group-I (test) was managed by SRP with intra-pocket application of 2% lemongrass oil gel. Group-II (control) was managed by SRP with intra-pocket application of a placebo gel. Periodontal pocket depth (PPD) and clinical attachment loss (CAL) were measured for both groups, before treatment and twelve weeks after. Moreover, GCF was collected from both groups at baseline, one week, and twelve weeks after treatment. Then analysed by Enzyme-linked Assay (ELISA) technique.

Enrollment: 40 patients

Sex: All

Ages: 25 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• systemically healthy individuals of both sexes having moderate periodontitis (stage II), CAL 3-4mm, with an age ranging from 25 to 45 years old.
• patients with no history of previous periodontal therapy or taken any antibiotic therapy for the past six months

Exclusion criteria

• history of smoking, previous adverse reaction to the products (or similar products) used in this study, grade C category that has rapid rate of progression, and pregnant or lactating women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Group I (test)

Experimental group

Description:

included twenty patients treated with SRP and intrapocket application of 2% lemongrass oil gel.

Treatment:

Drug: Cymbopogon citratus (lemongrass) oil gel

Group II (control)

Placebo Comparator group

Description:

included twenty treated with SRP and intrapocket application of placebo gel.

Treatment:

Drug: Cymbopogon citratus (lemongrass) oil gel