Cytogenetic Study of Ocular Melanoma

Jonsson Comprehensive Cancer Center

Status: Completed

Conditions: Choroidal Melanoma

Study type: Observational

Funder types: Other

Identifiers

NCT00344799

11-000847 (Other Identifier)

UCLA IRB#04-12-084

Details and patient eligibility

About

Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.

Full description

The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

Enrollment: 95 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient with diagnosis of ocular melanoma
2. Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation
3. Patient 18 years of age or older
4. Archival enucleation specimens with diagnosis of ocular melanoma

Exclusion criteria

1. Patient who refuses local melanoma treatment
2. Patient who refuses to participate in this study