Cytokine Filter Usage During Open Thoracoabdominal Aortic Aneurysm Repair- a Single-center Randomized Prospective Trial (TAAA-Cytosorb)

R

RWTH Aachen University

Status

Completed

Conditions

Postoperative Complications

Inflammatory Response

Treatments

Device: Cytosorb

Study type

Observational

Funder types

Other

Identifiers

NCT04765748

20-031

Details and patient eligibility

About

Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion.

Regardless an intensive inflammatory reaction is a well known effect after reperfusion, leading to a uncontrolled inflammation during th first days after surgery. This may be associated to bad outcome and decreased survival rates. By the application of a intraoperative cytokine and DAMP filter this negative ffect could be reduced, resulting in a better outcome after surgery.

Full description

Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion.

Regardless an intensive inflammatory reaction is a well known effect after reperfusion, leading to a uncontrolled inflammation during th first days after surgery. This may be associated to bad outcome and decreased survival rates. By the application of a intraoperative cytokine and DAMP filter this negative ffect could be reduced, resulting in a better outcome after surgery.

Trial design

20 participants in 2 patient groups

TAAA patients with Cytosorb

Description:

Patients suffering from a TAAA larger than 55mm

Treatment:

Device: Cytosorb

TAAA patients without Cytosorb

Description:

Patients suffering from a TAAA larger than 55mm

Trial contacts and locations

1

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