Cytokine Kinetics Test to Assess the Presence or Absence of Tolerance in Organ Transplant

University of Wisconsin (UW)

Status: Terminated

Conditions: Liver Transplantation; Kidney Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT00585858

H-2006-0437

Details and patient eligibility

About

The purpose of this pilot study is to determine if there is clinical correlation between the CKT and transplant recipients who are known to be on minimal or no immunosuppression (presumed tolerant) and those who are on conventional amounts of immunosuppression and have either experienced rejection (presumed hyper-responsive to donor) or have not experienced rejection (unknown responsive state).

Enrollment: 15 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Kidney or liver transplant recipients for whom donor cells are available

Exclusion criteria

• HcT <32%

Trial design

15 participants in 3 patient groups

1

Description:

Subjects on mimimal or no immunosuppression and no rejection history

2

Description:

Subjects who have had rejection on conventional immunosuppression

3

Description:

Subjects who have not had acute or chronic rejection who are on conventional immunosuppression