Cytokine Profiling Post-Heart Transplant

University of Minnesota (UMN)

Status: Terminated

Conditions: Cardiac Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT01643564

1111M06547

Details and patient eligibility

About

Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Group 1

• 18 years and older
• Cardiac Transplant recipient with graft dysfunction of unknown etiology

Group 2

• 18 years or older
• No history of heart failure or cardiac transplantation Group 3
• 18 years or older
• Class II-IV heart failure Group 4
• 18 years or older
• Heart Transplant 6 months or greater prior to blood draw
• No graft dysfunction

Exclusion criteria

Group 1 Heart Transplant with Unexplained Graft Dysfunction

• Cellular or antibody-mediated cardiac allograft dysfunction

Group 2 Normal Control group

• Active infection within 1 month of blood draw
• Known Inflammatory Disease

Group 3 Heart Failure Group

• Active infection within 1 month of blood draw
• Known Inflammatory Disease

Group 4 Heart Transplant with Normal Graft Function Group

• Active infection within 1 month of blood draw
• Known graft dysfunction
• Known Inflammatory Disease

Trial design

34 participants in 4 patient groups

Group 1

Description:

Heart Transplant Recipients with Unexplained Graft Dysfunction

Group 2

Description:

Normal Control

Group 3

Description:

Class III-IV Heart Failure

Group 4

Description:

Heart Transplant Recipients with Normal Graft Function