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Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination (CYF-8)

University of Aarhus logo

University of Aarhus

Status and phase

Active, not recruiting
Phase 4

Conditions

Healthy
Yellow Fever Vaccination Reaction
Cytotoxicity

Treatments

Drug: Yellow Fever Vaccine

Study type

Interventional

Funder types

Other

Identifiers

NCT04083430
YFV_001

Details and patient eligibility

About

Investigating cytotoxicity of yellow fever specific CD8 T cells following YF-17D vaccination and the following licensing of these epitope-specific CD8 T cells

Full description

CD: cluster of differentiation YF: yellow fever

Enrollment

60 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age between 18 to 60 years
  • Informed consent given

Exclusion criteria

  • Fever (orally >37,5 C) on day of vaccination
  • Immunosuppressants
  • Pregnant or breast feeding
  • Severe immunodeficiency
  • Known thymus dysfunction
  • Allergy against egg
  • Known haemophilia
  • Previous severe reaction to vaccine
  • Not willing to use anticonceptives 4 weeks after vaccination

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

60 participants in 1 patient group

Vaccine
Other group
Description:
Yellow Fever Vaccine
Treatment:
Drug: Yellow Fever Vaccine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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