Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination (CYF-8)

University of Aarhus

Status and phase: Active, not recruiting; Phase 4

Conditions: Healthy; Yellow Fever Vaccination Reaction; Cytotoxicity

Treatments: Drug: Yellow Fever Vaccine

Study type: Interventional

Funder types: Other

Identifiers

NCT04083430

YFV_001

Details and patient eligibility

About

Investigating cytotoxicity of yellow fever specific CD8 T cells following YF-17D vaccination and the following licensing of these epitope-specific CD8 T cells

Full description

CD: cluster of differentiation YF: yellow fever

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18 to 60 years
• Informed consent given

Exclusion criteria

• Fever (orally >37,5 C) on day of vaccination
• Immunosuppressants
• Pregnant or breast feeding
• Severe immunodeficiency
• Known thymus dysfunction
• Allergy against egg
• Known haemophilia
• Previous severe reaction to vaccine
• Not willing to use anticonceptives 4 weeks after vaccination

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Vaccine

Other group

Description:

Yellow Fever Vaccine

Treatment:

Drug: Yellow Fever Vaccine