D-Dimer Vs Serial Compression Ultrasound Study

Hamilton Health Sciences (HHS)

Status and phase: Completed; Phase 3

Conditions: Deep Vein Thrombosis

Treatments: Procedure: Serial Compression Ultrasound; Procedure: D-dimer

Study type: Interventional

Funder types: Other

Identifiers

NCT00182351

CTMG-1995-DDCUS

Details and patient eligibility

About

To determine whether d-dimer testing can be used to simplify and reduce the costs of the diagnostic approach to patients with clinically suspected deep vein thrombosis

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• first suspected deep vein thrombosis
• no previous venous thromboembolism
• referred to thromboembolism outpatient clinic

Exclusion criteria

• comorbid condition limiting survival to less than six months
• contraindication to venography (contrast allergy, etc.)
• receiving long term warfarin therapy
• receiving full dose heparin therapy for more than 48 hours
• absence of symptoms during the five days immediately prior to presentation
• symptoms of pulmonary embolism
• pregnancy
• geographic inaccessibility which precludes follow-up

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)