D Mannose for Prevention and Treatment of RUTIs (mannoseRUTIs)

IRCCS Policlinico S. Matteo

Status: Completed

Conditions: Antibiotic Resistance; Antibiotic Prophylaxis; Recurrent Urinary Tract Infections

Treatments: Other: systematic review

Study type: Observational

Funder types: Other

Identifiers

NCT03790254

ReviewUTIs

Details and patient eligibility

About

The aim of this review is to address clinical reliability, efficacy and safety of long-term treatment with oral D Mannose for the prevention of recurrent urinary tract infections (RUTIs) in females.

Full description

A comprehensive systematic MEDLINE, Embase, Cochrane search was performed for English language reports published before December 2018 using the term "recurrent urinary tract infections and d mannose." We searched Medline, Embase, and the Cochrane Register of Controlled Trials since January 2010 to December 2018. Eligible studies did not include non-oral therapy, local (vaginal) treatment in women with RUTIs.

Study eligibility criteria- We identified eligible original articles. The heterogeneity of the available studies, their different rationale and aim, the assumption of d mannose for prophylaxis or treatment of recurrent UTIs need to be taken into account.

Enrollment: 500 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

recurrent urinary tract infections (RUTIs)

Exclusion criteria

Upper urinary tract infections, severe clinical symptoms, fever > 37,5 with lumbar pain